S-Adenosylmethionine synthetase from human lymphocytes. Purification and characterization.

@article{Kotb1985SAdenosylmethionineSF,
  title={S-Adenosylmethionine synthetase from human lymphocytes. Purification and characterization.},
  author={Metwaly M. Kotb and Nicholas M. Kredich},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 7},
  pages={3923-30}
}
S-Adenosylmethionine synthetase has been purified to apparent homogeneity from human chronic lymphocytic leukemia cells. Equilibrium sedimentation studies and denaturing polyacrylamide gel electrophoresis indicate that the native enzyme has a molecular weight of 185,000 and a subunit composition of either alpha alpha' beta 2, alpha 2 beta 2, or alpha' 2 beta 2, where alpha, alpha', and beta are polypeptide chains of molecular weight 53,000, 51,000, and 38,000. The alpha and alpha' subunits… CONTINUE READING
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