S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial. [ISRCTN36233495]

@article{Najm2004SAdenosylM,
  title={S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial. [ISRCTN36233495]},
  author={Wadie I. Najm and Sibylle Reinsch and Fred K. Hoehler and Jerome S. Tobis and Phillip W Harvey},
  journal={BMC Musculoskeletal Disorders},
  year={2004},
  volume={5},
  pages={6 - 6}
}
BackgroundS-Adenosylmethionine (SAMe) is a dietary supplement used in the management of osteoarthritis (OA) symptoms. Studies evaluating SAMe in the management of OA have been limited to Non Steroidal Anti-inflammatory Drugs (NSAIDs) for comparison. The present study compares the effectiveness of SAMe to a cyclooxygenase-2 (COX-2) inhibitor (celecoxib) for pain control, functional improvement and to decrease side effects in people with osteoarthritis of the knee.MethodsA randomized double-blind… 
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References

SHOWING 1-10 OF 53 REFERENCES
Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis.
OBJECTIVE We assessed the efficacy of S-adenosylmethionine (SAMe), a dietary supplement now available in the Unites States, compared with that of placebo or nonsteroidal anti-inflammatory drugs
A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis.
TLDR
SAM may be an effective treatment for some patients with symptomatic knee OA, and merits further study, and intravenous loading before oral maintenance therapy may be advantageous.
Double-blind clinical trial of S-adenosylmethionine versus ibuprofen in the treatment of osteoarthritis.
[Pharmacological and clinical aspects of S-adenosylmethionine (SAMe) in primary degenerative arthropathy (osteoarthrosis)].
TLDR
An open trial, carried out on 90 patients with severe degenerative arthropathies has shown that 30 mg SAMe intravenously twice a day for 14 days have a marked anti-inflammatory effect a rather term and no side-effects.
Double-blind comparative clinical trial with S-adenosylmethionine and indomethacin in the treatment of osteoarthritis.
  • G. Vetter
  • Medicine, Psychology
    The American journal of medicine
  • 1987
Pain management in osteoarthritis: the role of COX-2 inhibitors.
  • N. Lane
  • Medicine
    The Journal of rheumatology. Supplement
  • 1997
TLDR
Short term studies in dental pain, OA, and rheumatoid arthritis found that the COX-2 inhibitor celecoxib was an effective analgesic but did not cause gastroduodenal erosions, and has the potential to provide analgesia and antiinflammatory action in patients with arthritis without the side effects of NSAID.
Epidemiology of NSAID induced gastrointestinal complications.
TLDR
Whether GI side effects such as dyspepsia can serve as warning symptoms for life-threatening GI complications and describes the risk factors for these events are described.
Effect of S-adenosylmethionine on experimental osteoarthritis in rabbits.
S-Adenosyl-L-methionine (SAMe): from the bench to the bedside--molecular basis of a pleiotrophic molecule.
  • T. Bottiglieri
  • Biology, Chemistry
    The American journal of clinical nutrition
  • 2002
TLDR
An overview of the biochemical, molecular, and therapeutic effects of SAMe is provided, including those on depression, dementia, vacuolar myelopathy, liver disease, and osteoarthritis.
...
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