S-Adenosyl-L-methionine–Dependent Restriction Enzymes

@article{Sistla2004SAdenosylLmethionineDependentRE,
  title={S-Adenosyl-L-methionine–Dependent Restriction Enzymes},
  author={S. Sistla and D. Rao},
  journal={Critical Reviews in Biochemistry and Molecular Biology},
  year={2004},
  volume={39},
  pages={1 - 19}
}
  • S. Sistla, D. Rao
  • Published 2004
  • Biology, Medicine
  • Critical Reviews in Biochemistry and Molecular Biology
Restriction–modification (R–M) enzymes are classified into type I, II, III, and IV, based on their recognition sequence, subunit composition, cleavage position, and cofactor requirements. While the role of S-Adenosyl-L-methionine (AdoMet) as the methyl group donor in the methylation reaction is undisputed, its requirement in DNA cleavage reaction has been subject to intense study. AdoMet is a prerequisite for the DNA cleavage by most type I enzymes known so far, with the exception of R.EcoR124I… Expand
Type I restriction endonucleases are true catalytic enzymes
Structural characterization of a modification subunit of a putative type I restriction enzyme from Vibrio vulnificus YJ016.
Structural model for the multisubunit Type IC restriction–modification DNA methyltransferase M.EcoR124I in complex with DNA
Diversity of DNA methyltransferases that recognize asymmetric target sequences
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