S-16924, a novel, potential antipsychotic with marked serotonin1A agonist properties. IV. A drug discrimination comparison with clozapine.

@article{Millan1999S16924AN,
  title={S-16924, a novel, potential antipsychotic with marked serotonin1A agonist properties. IV. A drug discrimination comparison with clozapine.},
  author={Mark John Millan and Robert J. Schreiber and S Monneyron and B Denorme and Christophe Melon and S Queriaux and Anne Dekeyne},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={289 1},
  pages={427-36}
}
The novel benzodioxopyrrolidine (S-16924) displays a clozapine-like profile of interaction with multiple monoaminergic receptors, in addition to potent agonist activity at serotonin (5-HT)1A receptors. S-16924 (2.5 mg/kg i.p.) and clozapine (5.0 mg/kg i.p.) generated robust discriminative stimuli (DS) and displayed full mutual generalization. The D4… CONTINUE READING