S‐adenosyl methionine decarboxylase activity is required for the outcome of herpes simplex virus type 1 infection and represents a new potential therapeutic target

  title={S‐adenosyl methionine decarboxylase activity is required for the outcome of herpes simplex virus type 1 infection and represents a new potential therapeutic target},
  author={Anna Greco and Aleth Callé and Florence Morfin and Danielle Thouvenot and Myriam Cayre and Karine Kindbeiter and Laetitia J. Martin and Olivier Levillain and Jean-Jacques Diaz},
  journal={The FASEB Journal},
All the available antiherpetic drugs are directed against viral proteins. Their extensive clinical use has led to the emergence of resistant viral strains. There is a need for the treatment of herpes infections due to resistant strains, especially for immunocompromised patients. To design new kinds of drugs, we have developed a strategy to identify cellular targets. Herpes simplex virus type 1 (HSV‐1) infection is concomitant to a repression of most host protein synthesis. However, some… 


The search for literature in international databases for information on promising developments that open new possibilities for treating herpesvirus infection and subsequent analysis of the collected data made it possible to determine not only the main trends in the search for new antiviral agents, but also to provide information on the compounds most promising for the development of anti-herpesvirus drugs.

Five Years of Progress on Cyclin-Dependent Kinases and other Cellular Proteins as Potential Targets for Antiviral Drugs

Significant progress has been made in the last 5 years in understanding the antiviral activities of PCIs and the potential roles of cellular proteins in general as targets for antivirals.

Diverse Functions of Polyamines in Virus Infection

Pharmacologically targeting polyamines, tipping the balance to favor the host and restrict virus replication, holds significant promise as a broad-spectrum antiviral strategy.

Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication

It is shown that cellular polyamines are critical for EBOV replication, and small-molecule inhibitors of polyamine synthesis block gene expression driven by the viral RNA-dependent RNA polymerase.

Étude de la sortie du virus herpès simplex de type 1 (HSV 1) hors du noyau

The modus operandi used by HSV-1 to leave cellular compartments such as the nucleus and the TGN is collected to detail and a sequential process that involved the acquisition of viral proteins UL36, UL37, ICP0, I CP8, UL41, UL42, US3 and possibly ICP4 on capsids released by the nucleus is investigated.

Targeting Polyamine Metabolism for Control of Human Viral Diseases

It is revealed that targeting polyamine metabolic pathways may be a potential approach to control human viral infection.

Polyamines and Their Role in Virus Infection

The diverse mechanisms in which viruses require polyamines are reviewed and blocking polyamine synthesis as a potential broad-spectrum antiviral approach is investigated.



Polyamine metabolism in MRC5 cells infected with different herpesviruses.

Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease

These studies validate the use of helicase-primase inhibitors for the treatment of acute herpesvirus infections and provide new lead compounds for optimization and design of superior anti-HSV agents.

Roles of polyamines in the replication of animal viruses.

It appears that the inhibition of virus production in polyamine-depleted cells is due in part to malfunction of protein synthetic machinery of the host cell.

The role of herpes simplex virus type 1 thymidine kinase in pathogenesis.

Inoculation of mice with the HSV TK deletion mutant resulted in the establishment of latent ganglionic infection as demonstrated by superinfection of explanted ganglia with wild-type (wt) virus but not by routine explant culture suggesting that the virus-encoded TK is not essential for theestablishment of latent infection but may be necessary for either reactivation or virus replication following reactivation.

Analysis of cyclin-dependent kinase activity after herpes simplex virus type 2 infection.

These studies indicate that HSV-2 infection selectively activates CDK2 after infection but cell-cycle progression does not occur, hypothesize that infection activates certain components of the cell cycle which enhance viral gene expression and DNA replication.

Charaterization by two‐dimensional gel electrophoresis of host proteins whose synthesis is sustained or stimulated during the course of herpes simplex virus type 1 infection

As expected, HSV‐1 induces a strong inhibition of host protein synthesis immediately after infection, however, the synthesis of basic ribosomal proteins and that of an unexpected high proportion of the sub‐set of cellular proteins analyzed is sustained or stimulated during HSv‐1 infection.

Phenotypic and Genetic Characterization of Thymidine Kinase from Clinical Strains of Varicella-Zoster Virus Resistant to Acyclovir

The phenotypic and genetic characterization of four ACV-resistant VZV strains isolated from AIDS patients and transplant recipients are reported and three areas in the TK gene where 71% of the mutations described to date are located are putative candidates for a genotypic diagnosis of ACV resistance.

Differential stability of host mRNAs in Friend erythroleukemia cells infected with herpes simplex virus type 1

It is concluded that the stabilization of preexisting histone H3 mRNA was responsible for the persistence of H3 RNA and histone protein synthesis in herpes simplex virus type 1-infected Friend erythroleukemia cells.

Herpes simplex virus resistance to antiviral drugs.

  • F. MorfinD. Thouvenot
  • Biology, Medicine
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2003