S‐adenosyl methionine decarboxylase activity is required for the outcome of herpes simplex virus type 1 infection and represents a new potential therapeutic target

@article{Greco2005SadenosylMD,
  title={S‐adenosyl methionine decarboxylase activity is required for the outcome of herpes simplex virus type 1 infection and represents a new potential therapeutic target},
  author={Anna Greco and Aleth Callé and Florence Morfin and Danielle Thouvenot and Myriam Cayre and Karine Kindbeiter and Laetitia J. Martin and Olivier Levillain and Jean-Jacques Diaz},
  journal={The FASEB Journal},
  year={2005},
  volume={19}
}
All the available antiherpetic drugs are directed against viral proteins. Their extensive clinical use has led to the emergence of resistant viral strains. There is a need for the treatment of herpes infections due to resistant strains, especially for immunocompromised patients. To design new kinds of drugs, we have developed a strategy to identify cellular targets. Herpes simplex virus type 1 (HSV‐1) infection is concomitant to a repression of most host protein synthesis. However, some… 

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