S‐adenosyl methionine decarboxylase activity is required for the outcome of herpes simplex virus type 1 infection and represents a new potential therapeutic target
@article{Greco2005SadenosylMD, title={S‐adenosyl methionine decarboxylase activity is required for the outcome of herpes simplex virus type 1 infection and represents a new potential therapeutic target}, author={Anna Greco and Aleth Callé and Florence Morfin and Danielle Thouvenot and Myriam Cayre and Karine Kindbeiter and Laetitia J. Martin and Olivier Levillain and Jean-Jacques Diaz}, journal={The FASEB Journal}, year={2005}, volume={19} }
All the available antiherpetic drugs are directed against viral proteins. Their extensive clinical use has led to the emergence of resistant viral strains. There is a need for the treatment of herpes infections due to resistant strains, especially for immunocompromised patients. To design new kinds of drugs, we have developed a strategy to identify cellular targets. Herpes simplex virus type 1 (HSV‐1) infection is concomitant to a repression of most host protein synthesis. However, some…
19 Citations
MODERN ETHIOTROPIC CHEMOTHERAPY OF HERPESVIRUS INFECTIONS: ADVANCES, NEW TRENDS AND PERSPECTIVES. ALPHAHERPESVIRINAE (part I).
- Chemistry, BiologyVoprosy virusologii
- 2018
The search for literature in international databases for information on promising developments that open new possibilities for treating herpesvirus infection and subsequent analysis of the collected data made it possible to determine not only the main trends in the search for new antiviral agents, but also to provide information on the compounds most promising for the development of anti-herpesvirus drugs.
Five Years of Progress on Cyclin-Dependent Kinases and other Cellular Proteins as Potential Targets for Antiviral Drugs
- Biology, ChemistryAntiviral chemistry & chemotherapy
- 2006
Significant progress has been made in the last 5 years in understanding the antiviral activities of PCIs and the potential roles of cellular proteins in general as targets for antivirals.
Diverse Functions of Polyamines in Virus Infection
- BiologyBiomolecules
- 2020
Pharmacologically targeting polyamines, tipping the balance to favor the host and restrict virus replication, holds significant promise as a broad-spectrum antiviral strategy.
Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication
- BiologymBio
- 2016
It is shown that cellular polyamines are critical for EBOV replication, and small-molecule inhibitors of polyamine synthesis block gene expression driven by the viral RNA-dependent RNA polymerase.
Polyamine regulation of porcine reproductive and respiratory syndrome virus infection depends on spermidine-spermine acetyltransferase 1
- BiologyVeterinary Microbiology
- 2020
Étude de la sortie du virus herpès simplex de type 1 (HSV 1) hors du noyau
- Biology
- 2010
The modus operandi used by HSV-1 to leave cellular compartments such as the nucleus and the TGN is collected to detail and a sequential process that involved the acquisition of viral proteins UL36, UL37, ICP0, I CP8, UL41, UL42, US3 and possibly ICP4 on capsids released by the nucleus is investigated.
Targeting Polyamine Metabolism for Control of Human Viral Diseases
- Biology, MedicineInfection and drug resistance
- 2020
It is revealed that targeting polyamine metabolic pathways may be a potential approach to control human viral infection.
Chlorella viruses contain genes encoding a complete polyamine biosynthetic pathway.
- BiologyVirology
- 2007
Polyamines and Their Role in Virus Infection
- BiologyMicrobiology and Molecular Biology Reviews
- 2017
The diverse mechanisms in which viruses require polyamines are reviewed and blocking polyamine synthesis as a potential broad-spectrum antiviral approach is investigated.
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