S‐Adenosylmetliionine and methylation

@article{Chiang1996SAdenosylmetliionineAM,
  title={S‐Adenosylmetliionine and methylation},
  author={Peter K. Chiang and Richard K. Gordon and Jacov Tal and Guichao Zeng and Bhupendra P. Doctor and Komanduri Pardhasaradhi and P Mccann},
  journal={The FASEB Journal},
  year={1996},
  volume={10},
  pages={471 - 480}
}
S‐Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events. Although it has been claimed that AdoMet itself has therapeutic benefits, it remains to be established whether it can be taken up intact by cells. S‐Adeno‐ sylhomocysteine (AdoHcy), formed after donation of the methyl group of AdoMet to a methyl acceptor, is then hydrolyzed to adenosine and homocysteine by AdoHcy hydrolase. This enzyme has long been a target for… Expand
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  • P. Chiang
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  • Pharmacology & therapeutics
  • 1998
TLDR
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The data support an alternative mechanism of action for AdoMet as an inhibitor of intracellular demethylase activity, which results in hypermethylation of DNA. Expand
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