S‐Adenosylmetliionine and methylation

@article{Chiang1996SAdenosylmetliionineAM,
  title={S‐Adenosylmetliionine and methylation},
  author={Petek K. Chiang and Richard K. Gordon and Jacov Tal and Guang Zeng and Bhupendra P. Doctor and Komanduri Pardhasaradhi and Peter P. McCann},
  journal={The FASEB Journal},
  year={1996},
  volume={10},
  pages={471 - 480}
}
S‐Adenosylmethionine (AdoMet or SAM) plays a pivotal role as a methyl donor in a myriad of biological and biochemical events. Although it has been claimed that AdoMet itself has therapeutic benefits, it remains to be established whether it can be taken up intact by cells. S‐Adeno‐ sylhomocysteine (AdoHcy), formed after donation of the methyl group of AdoMet to a methyl acceptor, is then hydrolyzed to adenosine and homocysteine by AdoHcy hydrolase. This enzyme has long been a target for… 

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