S‐Adenosyl‐L‐methionine in the treatment of patients with intrahepatic cholestasis of pregnancy: A randomized, double‐blind, placebo‐controlled study with negative results

@article{Ribalta1991SAdenosylLmethionineIT,
  title={S‐Adenosyl‐L‐methionine in the treatment of patients with intrahepatic cholestasis of pregnancy: A randomized, double‐blind, placebo‐controlled study with negative results},
  author={J. Ribalta and H. Reyes and M. Gonz{\'a}lez and J. Iglesias and M. Arrese and J. Poniachik and C. Molina and N. Segovia},
  journal={Hepatology},
  year={1991},
  volume={13}
}
S‐Adenosyl‐L‐methionine has been reported to induce beneficial effects in intrahepatic cholestasis of pregnancy. Because cholestasis of pregnancy has a high prevalence in Chile and a deleterious effect on fetal prognosis, we decided to verify the efficacy of S‐adenosyl‐L‐methionine in this disease. Eighteen patients with pruritus that appeared during pregnancy and with elevated serum levels of bile salts (68.1 ± 15.9 μmol/L; mean ± S.E.M.) and ALT (226 ± 50 KU/L) were enrolled in a prospective… Expand
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