Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.

@article{Lahm2007RynaxypyrAN,
  title={Rynaxypyr: a new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator.},
  author={George P. Lahm and Thomas M Stevenson and Thomas P Selby and John H Freudenberger and Daniel Andr{\'e}s C{\'o}rdova and Lindsey Flexner and Cheryl A Bellin and Christine M Dubas and Ben H. Smith and Kenneth A Hughes and J Gary Hollingshaus and Christopher Elles Clark and Eric A. Benner},
  journal={Bioorganic & medicinal chemistry letters},
  year={2007},
  volume={17 22},
  pages={6274-9}
}
Rynaxypyr is a highly potent and selective activator of insect ryanodine receptors with exceptional activity on a broad range of Lepidoptera. A strong correlation between insecticidal activity and ryanodine receptor activation is observed along with selective activity against insect over mammalian receptors. The synthesis and biological results are presented. 

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