Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons.

@article{Blakely2013RykAR,
  title={Ryk, a receptor regulating Wnt5a-mediated neurogenesis and axon morphogenesis of ventral midbrain dopaminergic neurons.},
  author={Brette D. Blakely and Christopher R. Bye and Chathurini V. Fernando and Asheeta A Prasad and R Jeroen Pasterkamp and Maria L. Macheda and Steven A Stacker and Clare L. Parish},
  journal={Stem cells and development},
  year={2013},
  volume={22 15},
  pages={2132-44}
}
Ryk is an atypical transmembrane receptor tyrosine kinase that has been shown to play multiple roles in development through the modulation of Wnt signaling. Within the developing ventral midbrain (VM), Wnts have been shown to contribute to the proliferation, differentiation, and connectivity of dopamine (DA) neurons; however, the Wnt-related receptors regulating these events remain less well described. In light of the established roles of Wnt5a in dopaminergic development (regulating DA… CONTINUE READING
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