Ryanodine-sensitive intracellular Ca2+ channels in rat suprachiasmatic nuclei are required for circadian clock control of behavior.

@article{Mercado2009RyanodinesensitiveIC,
  title={Ryanodine-sensitive intracellular Ca2+ channels in rat suprachiasmatic nuclei are required for circadian clock control of behavior.},
  author={Clara Mercado and Mauricio D{\'i}az-Mu{\~n}oz and Javier Alamilla and Karla Valderrama and Ver{\'o}nica Morales-Tlalpan and Ra{\'u}l Aguilar-Roblero},
  journal={Journal of biological rhythms},
  year={2009},
  volume={24 3},
  pages={203-10}
}
Electrophysiological and calcium mobilization experiments have suggested that the intracellular calcium release channel ryanodine receptors (RyRs) are involved in the circadian rhythmicity of the suprachiasmatic nucleus (SCN). In the present report the authors provide behavioral evidence that RyRs play a specific and major role in the output of the molecular circadian clock in SCN neurons. They measured the circadian rhythm of drinking and locomotor behaviors in dim red light before, during… CONTINUE READING
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