Ryanodine receptors and BK channels act as a presynaptic depressor of neurotransmission in cochlear inner hair cells.

@article{Beurg2005RyanodineRA,
  title={Ryanodine receptors and BK channels act as a presynaptic depressor of neurotransmission in cochlear inner hair cells.},
  author={Maryline Beurg and A. Alaoui Hafidi and Liam J. Skinner and J{\'e}r{\^o}me Ruel and R{\'e}gis Nouvian and Morgana H{\'e}naff and Jean-Luc Puel and J M Aran and Didier Dulon},
  journal={The European journal of neuroscience},
  year={2005},
  volume={22 5},
  pages={1109-19}
}
Ryanodine receptors (RyRs) are known to contribute to the regulation of free cytosolic calcium concentration. This family of intracellular calcium channels plays a significant role in calcium-induced-calcium-release (CICR), and have been implicated in calcium-dependent processes requiring exquisite spatio-temporal regulation. In order to characterize the importance of these intracellular calcium channels in cochlear physiology, we perfused the guinea pig cochlea with antagonistic concentrations… CONTINUE READING