Ryanodine receptor sensitization results in abnormal calcium signaling in airway smooth muscle cells.

@article{Croisier2015RyanodineRS,
  title={Ryanodine receptor sensitization results in abnormal calcium signaling in airway smooth muscle cells.},
  author={Huguette Croisier and Xiahui Tan and Jun Chen and James Sneyd and Michael J. Sanderson and Bindi S. Brook},
  journal={American journal of respiratory cell and molecular biology},
  year={2015},
  volume={53 5},
  pages={703-11}
}
Intracellular Ca(2+) dynamics of airway smooth muscle cells (ASMCs) are believed to play a major role in airway hyperresponsiveness and remodeling in asthma. Prior studies have underscored a prominent role for inositol 1,4,5-triphosphate (IP3) receptors in normal agonist-induced Ca(2+) oscillations, whereas ryanodine receptors (RyRs) appear to remain closed during such Ca(2+) oscillations, which mediate ASMC contraction. Nevertheless, RyRs have been hypothesized to play a role in… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS