Ryanodine receptor physiology and its role in disease.

  title={Ryanodine receptor physiology and its role in disease.},
  author={Johanna T Lanner},
  journal={Advances in experimental medicine and biology},
The ryanodine receptors (RyRs) is the major intracellular Ca(2+) release channel localized in the plasma membrane of the endoplasmatic/sarcoplasmatic reticulum. RyR-mediated Ca(2+) release is crucial for every heart beat and skeletal muscle contraction and also important in learning and memory. Given the important role RyR has in physiological functions it is not surprising that dysregulation and impaired RyR channel function contributes to severe pathologies e.g. cardiac arrhythmias and… CONTINUE READING


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