Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation.

@article{Lee2005RyanodineRI,
  title={Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation.},
  author={Sang Min Lee and Jae Woong Lee and Youn Sook Song and Dae Youn Hwang and Yong Kyu Kim and Sang Yun Nam and Dae Joong Kim and Young Won Yun and Do-Young Yoon and Jin Tae Hong},
  journal={Journal of neuroscience research},
  year={2005},
  volume={82 4},
  pages={542-50}
}
Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much perturbed in mutant-type PS2 with elevated ryanodine-receptor (RyR) expression and intracellular calcium levels. Moreover, dantrolene, a blocker of RyR reduced the PS2 mutation… CONTINUE READING