Ryanodine does not affect calcium current in guinea pig ventricular myocytes in which Ca2+ is buffered.

@article{Balke1991RyanodineDN,
  title={Ryanodine does not affect calcium current in guinea pig ventricular myocytes in which Ca2+ is buffered.},
  author={C. William Balke and W. Gil Wier},
  journal={Circulation research},
  year={1991},
  volume={68 3},
  pages={897-902}
}
Calcium current in mammalian ventricular muscle is altered in the presence of ryanodine. Previous studies performed on rat ventricular cells have shown a slowing of Ca2+ current inactivation and suggest the hypothesis that ryanodine, by reducing the release of Ca2+ from the sarcoplasmic reticulum, reduces the availability of Ca2+ for inactivation of Ca2… CONTINUE READING