Ryanodine alteration of the contractile state of rat ventricular myocardium. Comparison with dog, cat, and rabbit ventricular tissues.

@article{Sutko1980RyanodineAO,
  title={Ryanodine alteration of the contractile state of rat ventricular myocardium. Comparison with dog, cat, and rabbit ventricular tissues.},
  author={John L. Sutko and James T. Willerson},
  journal={Circulation research},
  year={1980},
  volume={46 3},
  pages={332-43}
}
To test the hypothesis that ryanodine inhibits the release of contractile Ca from intracellular stores, we compared the contractile responses by rabbit, cat, dog, and rat papillary muscles to ryanodine. Results of cumulative ryanodine concentration (10~ to 10~ M) response studies indicate the following order of sensitivity to ryanodine: rat > dog = cat > rabbit which mimics the relative dependence of these species on intracellular Ca for force development. In the presence of 2.5 mM [Ca… CONTINUE READING

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