• Published 2004

RyR 2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca 2 release ( SOICR )

@inproceedings{Jiang2004RyR2M,
  title={RyR 2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca 2 release ( SOICR )},
  author={Dawei Jiang and Bailong Xiao and Dongmei Yang and Ruiwu Wang and Philip M.C. Choi and Lin Zhang and Heping Cheng and S R Wayne Chen},
  year={2004}
}
The cardiac ryanodine receptor (RyR2) governs the release of Ca2 from the sarcoplasmic reticulum, which initiates muscle contraction. Mutations in RyR2 have been linked to ventricular tachycardia (VT) and sudden death, but the precise molecular mechanism is unclear. It is known that when the sarcoplasmic reticulum store Ca2 content reaches a critical level, spontaneous Ca2 release occurs, a process we refer to as store-overload-induced Ca2 release (SOICR). In view of the well documented… CONTINUE READING

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Dynamic distribution of ryanodine receptors in cardiac muscles

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Ligand-dependent conformational changes in the clamp region of the cardiac ryanodine receptor.

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Mechanistic models for muscle diseases and disorders originating in the sarcoplasmic reticulum.

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