Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.

@article{Yang2007Rv1106cFM,
  title={Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.},
  author={X. Yang and E. Dubnau and I. Smith and N. Sampson},
  journal={Biochemistry},
  year={2007},
  volume={46 31},
  pages={
          9058-67
        }
}
  • X. Yang, E. Dubnau, +1 author N. Sampson
  • Published 2007
  • Biology, Medicine
  • Biochemistry
  • New approaches are required to combat Mycobacterium tuberculosis (Mtb), especially the multi-drug resistant and extremely drug resistant organisms (MDR-TB and XDR-TB). There are many reports that mycobacteria oxidize 3beta-hydroxysterols to 3-ketosteroids, but the enzymes responsible for this activity have not been identified in mycobacterial species. In this work, the Rv1106c gene that is annotated as a 3beta-hydroxysteroid dehydrogenase in Mtb has been cloned and heterologously expressed. The… CONTINUE READING
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