Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.

  title={Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.},
  author={X. Yang and E. Dubnau and I. Smith and N. Sampson},
  volume={46 31},
  • X. Yang, E. Dubnau, +1 author N. Sampson
  • Published 2007
  • Biology, Medicine
  • Biochemistry
  • New approaches are required to combat Mycobacterium tuberculosis (Mtb), especially the multi-drug resistant and extremely drug resistant organisms (MDR-TB and XDR-TB). There are many reports that mycobacteria oxidize 3beta-hydroxysterols to 3-ketosteroids, but the enzymes responsible for this activity have not been identified in mycobacterial species. In this work, the Rv1106c gene that is annotated as a 3beta-hydroxysteroid dehydrogenase in Mtb has been cloned and heterologously expressed. The… CONTINUE READING
    85 Citations
    Inhibition of the M. tuberculosis 3β-hydroxysteroid dehydrogenase by azasteroids.
    • 13
    Mycobacterial Cytochrome P450 125 (Cyp125) Catalyzes the Terminal Hydroxylation of C27 Steroids*
    • 129
    • PDF
    A Thiolase of Mycobacterium tuberculosis Is Required for Virulence and Production of Androstenedione and Androstadienedione from Cholesterol
    • 134
    • PDF
    Regulation of the KstR2 regulon of Mycobacterium tuberculosis by a cholesterol catabolite
    • 38
    • Highly Influenced