Rv1027c-Rv1028c encode functional KdpDE two--component system in Mycobacterium tuberculosis.

@article{Agrawal2014Rv1027cRv1028cEF,
  title={Rv1027c-Rv1028c encode functional KdpDE two--component system in Mycobacterium tuberculosis.},
  author={Ruchi Agrawal and Deepak Kumar Saini},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={446 4},
  pages={1172-8}
}
In Mycobacteriumtuberculosis Rv1027c-Rv1028c genes are predicted to encode KdpDE two component system, which is highly conserved across all bacterial species. Here, we show that the system is functionally active and KdpD sensor kinase undergoes autophosphorylation and transfers phosphoryl group to KdpE, response regulator protein. We identified His(642) and Asp(52) as conserved phosphorylation sites in KdpD and KdpE respectively and by SPR analysis confirmed the physical interaction between… CONTINUE READING

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