Ruxolitinib: a potential treatment for corticosteroid refractory acute graft-versus-host disease

@article{Abedin2020RuxolitinibAP,
  title={Ruxolitinib: a potential treatment for corticosteroid refractory acute graft-versus-host disease},
  author={S. Abedin and M. Hamadani},
  journal={Expert Opinion on Investigational Drugs},
  year={2020},
  volume={29},
  pages={423 - 427}
}
  • S. Abedin, M. Hamadani
  • Published 2020
  • Medicine
  • Expert Opinion on Investigational Drugs
  • ABSTRACT Introduction Allogeneic transplantation represents a potentially curative procedure for various lethal conditions; however, it is associated with serious immune mediated complications. The most serious complication is graft-versus-host disease (GVHD). Acute GVHD (aGVHD) is unresponsive to initial corticosteroid therapy in ~40% of cases. Corticosteroid-refractory aGVHD (CR-aGVHD) represents a significant unmet need with nearly 60% mortality in patients developing this state. Areas… CONTINUE READING
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