RuvAB Acts at Arrested Replication Forks

  title={RuvAB Acts at Arrested Replication Forks},
  author={Marie Seigneur and Vladimir Bidnenko and S. Dusko Ehrlich and B{\'e}n{\'e}dicte Michel},
Replication arrest leads to the occurrence of DNA double-stranded breaks (DSB). We studied the mechanism of DSB formation by direct measure of the amount of in vivo linear DNA in Escherichia coli cells that lack the RecBCD recombination complex and by genetic means. The RuvABC proteins, which catalyze migration and cleavage of Holliday junctions, are responsible for the occurrence of DSBs at arrested replication forks. In cells proficient for RecBC, RuvAB is uncoupled from RuvC and DSBs may be… CONTINUE READING
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