Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test.

@article{Noeldner2002RutinIE,
  title={Rutin is essential for the antidepressant activity of Hypericum perforatum extracts in the forced swimming test.},
  author={Michael Noeldner and Karl Schoetz},
  journal={Planta medica},
  year={2002},
  volume={68 7},
  pages={577-80}
}
It has been shown that aqueous alcoholic extracts of Hypericum perforatum (St. John's wort) are active in the forced swimming test (FST), an animal model for antidepressant activity. In this study, a series of ethanolic and methanolic extracts were investigated and, in almost all cases, the extracts showed strong activity. Only one methanolic research extract had no effect in the in vivo pharmacological experiments. Analytical characterisation using HPLC showed that the inactive extract had a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Similar Papers

Loading similar papers…