Rutin increases the cytotoxicity of temozolomide in glioblastoma via autophagy inhibition

@article{Zhang2017RutinIT,
  title={Rutin increases the cytotoxicity of temozolomide in glioblastoma via autophagy inhibition},
  author={Pingde Zhang and Stella Sun and Ning Li and Amy Suk Wai Ho and Karrie Mei Yee Kiang and Xiaoqin Zhang and Yin Stephen Cheng and Ming Wai Poon and D. W. K. Lee and Jenny Kan Suen Pu and Gilberto Ka-Kit Leung},
  journal={Journal of Neuro-Oncology},
  year={2017},
  volume={132},
  pages={393-400}
}
The chemotherapeutic agent temozolomide (TMZ) is widely used in the treatment of glioblastoma multiforme (GBM). Rutin, a citrus flavonoid ecglycoside found in edible plants, has neuroprotective and anticancer activities. This study aimed to investigate the efficacy and the underlying mechanisms of rutin used in combination with TMZ in GBM. In vitro cell viability assay demonstrated that rutin alone had generally low cytotoxic effect, but it enhanced the efficacy of TMZ in a dose-dependent… CONTINUE READING
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