Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects

@article{Gautam2016RutinAI,
  title={Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects},
  author={Raju Gautam and Manjari Singh and Swetlana Gautam and Jitendra Kumar Rawat and Shubhini A. Saraf and Gaurav Kaithwas},
  journal={BMC Complementary and Alternative Medicine},
  year={2016},
  volume={16}
}
BackgroundMethotrexate (MTX) is recognized as an anti-metabolite in cancer chemotherapy and is associated with various toxicities assigned to inflammation and oxidative stress. Rutin has been reported to have significant anti-inflammatory, antioxidant along with antiulcer properties. The present study was undertaken to corroborate the effect of rutin against MTX induced intestinal toxicity in experimental animals.MethodSix groups of rats (n = 6) were dosed with normal saline (3 ml/kg,i.p.); MTX… Expand
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References

SHOWING 1-10 OF 54 REFERENCES
Preclinical Efficacy of Melatonin to Reduce Methotrexate-Induced Oxidative Stress and Small Intestinal Damage in Rats
TLDR
The results of the present study demonstrate that supplementation by exogenous melatonin significantly reduces MTX-induced small intestinal damage, indicating that it may be beneficial in ameliorating MTx-induced enteritis in humans. Expand
Protective Effect of Ethyl Pyruvate on Epididymal Sperm Characteristics, Oxidative Stress and Testosterone Level in Methotrexate Treated Mice
TLDR
It can be concluded that MTX induced toxicity in sperm parameters and serum level of testosterone and increased MDA level and EP with its antioxidant properties could be administrated during treatment with MTX due to its protective effects on sperm parameters, plasma testosterone levels and lipid peroxidation. Expand
Mitochondrial dysfunction and respiratory chain defects in a rodent model of methotrexate-induced enteritis
TLDR
The results of the present study suggest that MTX-induced damage to enterocyte mitochondria may play a critical role in enteritis, and methotrexate-induced alteration in mitochondrial structure may cause its dysfunction and decreases the activities of the electron chain complexes. Expand
Role of inducible nitric oxide synthase pathway on methotrexate-induced intestinal mucositis in rodents
TLDR
The results suggest an important role of nitric oxide, via activation of iNOS, in the pathogenesis of intestinal mucositis, as indicated by the reduced villus and crypt damages, inflammatory alterations, cell death, MPO activity, and nitrotyrosine immunostaining due to MTX challenge. Expand
Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production
TLDR
It is found MTX could induce caspase-dependent apoptosis and promote ROS generation together with disrupting the mitochondrial membrane potential of HL-60 and Jurkat T cells and demonstrate that MTX-induced apoptosis is ROS-dependent and occurs along a mitochondria-mediated pathway. Expand
Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions.
TLDR
The results suggest that the gastroprotective effect of rutin in this experimental model appears through an anti-lipoperoxidants effect, and also by enhancement of the anti-oxidant enzymatic activity. Expand
Effects of ethanol extract of Ficus bengalensis (bark) on inflammatory bowel disease
TLDR
It is found that AEFB has a significant protective effect in the IBD in rats that is comparable to that of prednisolone and may be because of the presence of flavonoids, terpenoids, and phenolic compounds. Expand
Understanding and managing methotrexate nephrotoxicity.
TLDR
CPDG(2) administration has been well tolerated and resulted in consistent and rapid reductions in plasma MTX concentrations by a median of 98.7% (range, 84%-99.5%). Expand
Effect of aloe vera (Aloe barbadensis Miller) gel on doxorubicin-induced myocardial oxidative stress and calcium overload in albino rats.
TLDR
The results revealed that A. vera gel produced a dose dependent protection against DOX induced cardiotoxiaty, evidenced by significant reductions in serum LDH, serum CPK, cardiac lipid peroxides, tissue catalase and tissue SOD along with increased levels of blood and tissue GSH. Expand
Combination therapy of gamma-aminobutyric acid derivative promotes proton pump inhibitor based healing of reflux esophagitis in animal model.
TLDR
The beneficial effect of omeprazole and baclofen against GERD could be conglomerately attributed to the antisectretory action of omepsiazole and reduction in the tracheal lower esophageal sphincter release rate by bacl ofen. Expand
...
1
2
3
4
5
...