Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells

@article{Iriti2017RutinAQ,
  title={Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells},
  author={Marcello Iriti and Robert Kubina and Andrea Cochis and Rita Sorrentino and Elena Maria Varoni and Agata Kabała-Dzik and Barbara Azzimonti and Arkadiusz Dziedzic and Lia Rimondini and Robert Dariusz Wojtyczka},
  journal={Phytotherapy Research},
  year={2017},
  volume={31},
  pages={1529 - 1538}
}
Several studies have documented the ability of flavonoids to sensitize cancer cells to chemotherapeutics and reverse multidrug resistance by inhibition of efflux pumps (adenosine triphosphate‐binding cassette transporters), apoptosis activation, and cell cycle arrest. In this study, the flavonoid rutin (quercetin 3‐O‐β‐d‐rutinoside) was investigated as chemosensitizer towards two different human epithelial breast cancer cell lines: (i) MB‐MDA‐231, selected as representative for triple‐negative… Expand
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