Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15.

@article{Wang2014RuthmycinAN,
  title={Ruthmycin, a new tetracyclic polyketide from Streptomyces sp. RM-4-15.},
  author={Xiachang Wang and Sherif I. Elshahawi and Khaled A. Shaaban and Lei Fang and Larissa V. Ponomareva and Yinan Zhang and Gregory C. Copley and James C. Hower and Chang-Guo Zhan and Madan K. Kharel and Jon S. Thorson},
  journal={Organic letters},
  year={2014},
  volume={16 2},
  pages={
          456-9
        }
}
The isolation and structural elucidation of a new tetracyclic polyketide (ruthmycin) from Streptomyces sp. RM-4-15, a bacteria isolated near thermal vents from the Ruth Mullins underground coal mine fire in eastern Kentucky, is reported. In comparison to the well-established frenolicin core scaffold, ruthmycin possesses an unprecedented signature C3 bridge and a corresponding fused six member ring. Preliminary in vitro antibacterial, anticancer, and antifungal assays revealed ruthmycin to… 

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