Ruthenium red inhibits TASK-3 potassium channel by interconnecting glutamate 70 of the two subunits.

@article{Czirjk2003RutheniumRI,
  title={Ruthenium red inhibits TASK-3 potassium channel by interconnecting glutamate 70 of the two subunits.},
  author={G{\'a}bor Czirj{\'a}k and P{\'e}ter Enyedi},
  journal={Molecular pharmacology},
  year={2003},
  volume={63 3},
  pages={646-52}
}
TASK channels are highly pH-sensitive two-pore-domain background potassium channels expressed in the central nervous system and in some peripheral tissues. Their current can be regulated by receptor-mediated activation of phospholipase C and also by pharmacological means. We have reported previously that the cationic dye, ruthenium red (RR), inhibited homodimeric TASK-3 (kcnk9), whereas TASK-1 (kcnk3) homodimer and TASK-1/TASK-3 heterodimer were not affected by this compound. In the present… CONTINUE READING
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