Ruthenium oligonucleotides, targeting HPV16 E6 oncogene, inhibit the growth of cervical cancer cells under illumination by a mechanism involving p53

@article{Reschner2013RutheniumOT,
  title={Ruthenium oligonucleotides, targeting HPV16 E6 oncogene, inhibit the growth of cervical cancer cells under illumination by a mechanism involving p53},
  author={Anca Reschner and S{\'e}bastien Bontems and Severine Le Gac and Javiera Lambermont and Lionel Marc{\'e}lis and Eric Defrancq and Pascale Hubert and C{\'e}cile Moucheron and Andr{\'e}e Kirsch-De Mesmaeker and Martine Raes and Jacques Piette and Philippe O Delvenne},
  journal={Gene Therapy},
  year={2013},
  volume={20},
  pages={435-443}
}
High-risk Human Papillomaviruses (HPV) has been found to be associated with carcinomas of the cervix, penis, vulva/vagina, anus, mouth and oro-pharynx. As the main tumorigenic effects of the HPV have been attributed to the expression of E6 and E7 genes, different gene therapy approaches have been directed to block their expression such as antisense oligonucleotides (ASO), ribozymes and small interfering RNAs. In order to develop a gene-specific therapy for HPV-related cancers, we investigated a… CONTINUE READING
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