Ruthenium-catalyzed azide-alkyne cycloaddition: scope and mechanism.

  title={Ruthenium-catalyzed azide-alkyne cycloaddition: scope and mechanism.},
  author={Brant Clayton Boren and Sridhar Narayan and Lars Kyhn Rasmussen and Li Zhang and Haitao Zhao and Zhenyang Lin and Guochen Jia and Valery V Fokin},
  journal={Journal of the American Chemical Society},
  volume={130 28},
The catalytic activity of a series of ruthenium(II) complexes in azide-alkyne cycloadditions has been evaluated. The [Cp*RuCl] complexes, such as Cp*RuCl(PPh 3) 2, Cp*RuCl(COD), and Cp*RuCl(NBD), were among the most effective catalysts. In the presence of catalytic Cp*RuCl(PPh 3) 2 or Cp*RuCl(COD), primary and secondary azides react with a broad range of terminal alkynes containing a range of functionalities selectively producing 1,5-disubstituted 1,2,3-triazoles; tertiary azides were… CONTINUE READING