Ruthenium-Catalyzed Urea Synthesis by N-H Activation of Amines.

@article{Krishnakumar2017RutheniumCatalyzedUS,
  title={Ruthenium-Catalyzed Urea Synthesis by N-H Activation of Amines.},
  author={V. Krishnakumar and Basujit Chatterjee and C. Gunanathan},
  journal={Inorganic chemistry},
  year={2017},
  volume={56 12},
  pages={
          7278-7284
        }
}
  • V. Krishnakumar, Basujit Chatterjee, C. Gunanathan
  • Published 2017
  • Chemistry, Medicine
  • Inorganic chemistry
  • Activation of the N-H bond of amines by a ruthenium pincer complex operating via "amine-amide" metal-ligand cooperation is demonstrated. Catalytic formyl C-H activation of N,N-dimethylformamide (DMF) is observed in situ, which resulted in the formation of CO and dimethylamine. The scope of this new mode of bond activation is extended to the synthesis of urea derivatives from amines using DMF as a carbon monoxide (CO) surrogate. This catalytic protocol allows the synthesis of simple and… CONTINUE READING
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