Ruthenium-Catalyzed Cycloisomerization of 2-Alkynylanilides: Synthesis of 3-Substituted Indoles by 1,2-Carbon Migration.

Abstract

We developed ruthenium-catalyzed cycloisomerization of alkynylanilides that gave 3-substituted indoles in high yields. The reaction proceeded via the disubstituted vinylidene ruthenium complex that was formed by the 1,2-carbon migration. 
DOI: 10.1021/jacs.7b04564

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Cite this paper

@article{Watanabe2017RutheniumCatalyzedCO, title={Ruthenium-Catalyzed Cycloisomerization of 2-Alkynylanilides: Synthesis of 3-Substituted Indoles by 1,2-Carbon Migration.}, author={Takuma Watanabe and Yuichiro Mutoh and Shinichi Saito}, journal={Journal of the American Chemical Society}, year={2017}, volume={139 23}, pages={7749-7752} }