Ruthenium-Catalyzed Cascade C—H Functionalization of Phenylacetophenones**

Abstract

Three orthogonal cascade CH functionalization processes are described, based on ruthenium-catalyzed CH alkenylation. 1-Indanones, indeno indenes, and indeno furanones were accessed through cascade pathways by using arylacetophenones as substrates under conditions of catalytic [{Ru(p-cymene)Cl2 }2 ] and stoichiometric Cu(OAc)2 . Each transformation uses CH functionalization methods to form CC bonds sequentially, with the indeno furanone synthesis featuring a CO bond formation as the terminating step. This work demonstrates the power of ruthenium-catalyzed alkenylation as a platform reaction to develop more complex transformations, with multiple CH functionalization steps taking place in a single operation to access novel carbocyclic structures.

DOI: 10.1002/anie.201309114

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Cite this paper

@inproceedings{Mehta2014RutheniumCatalyzedCC, title={Ruthenium-Catalyzed Cascade C—H Functionalization of Phenylacetophenones**}, author={Vaibhav Pravinchandra Mehta and Jos{\'e}-Antonio Garc{\'i}a-L{\'o}pez and Michael F Greaney}, booktitle={Angewandte Chemie}, year={2014} }