Rutaecarpine prevented dysfunction of endothelial gap junction induced by Ox-LDL via activation of TRPV1.

@article{Peng2015RutaecarpinePD,
  title={Rutaecarpine prevented dysfunction of endothelial gap junction induced by Ox-LDL via activation of TRPV1.},
  author={Wenjian Peng and Yong Liu and Yongmei Yu and Yan-Qi Fu and Yan Zhao and Hai-Bing Kuang and Qi-ren Huang and Ming He and Dan Luo},
  journal={European journal of pharmacology},
  year={2015},
  volume={756},
  pages={
          8-14
        }
}
Gap junctions, which is formed by connexins, has been proved to play an important role in the atherogenesis development. Rutaecarpine was reported to inhibited monocyte migration, which indicates its potential for anti-atherosclerosis activity. This study evaluated the effect of rutaecarpine on endothelial dysfunction, and focused on the regulation of connexin expression in endothelial cells by rutaecarpine. Endothelia damage was induced by exposing HUVEC-12 to Ox-LDL (100mg/l) for 24h, which… CONTINUE READING
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