Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival.

@article{Fadlalla2011RutaGE,
  title={Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival.},
  author={Khalda Fadlalla and Angela E Watson and Teshome E Yehualaeshet and Timothy Turner and Temesgen Samuel},
  journal={Anticancer research},
  year={2011},
  volume={31 1},
  pages={
          233-41
        }
}
BACKGROUND Ruta graveolens is a medicinal herb that has been used for centuries against various ailments. This study examined the anticancer properties of the herb using cancer cell lines. MATERIALS AND METHODS Methanolic extract of R. graveolens was tested on colon, breast and prostate cancer cells. Viability, cell cycle profiles, clonogenicity and capase activation were measured. Induction and subcellular localizations of p53, 53BP1 and γ-H2AX proteins were examined. RESULTS The extract… CONTINUE READING
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