Rust and corrosion in hematopoietic stem cell transplantation: the problem of iron and oxidative stress

@article{Evens2004RustAC,
  title={Rust and corrosion in hematopoietic stem cell transplantation: the problem of iron and oxidative stress},
  author={Andrew M. Evens and Jayesh Mehta and Leo I. Gordon},
  journal={Bone Marrow Transplantation},
  year={2004},
  volume={34},
  pages={561-571}
}
Summary:Iron overload is a common acute and long-term event associated with autologous and allogeneic hematopoietic stem cell transplantation (HSCT). In a state of iron excess, free iron becomes available to catalyze the conversion of reactive oxygen species (ROS) intermediates such as superoxide anion (O2•−) and hydrogen peroxide (H2O2) to highly toxic free radicals such as hydroxyl radical (OH•). ROS may help to promote chronic liver disease, sinusoidal obstruction syndrome, idiopathic… 
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Iron overload and allogeneic hematopoietic stem-cell

Iron-chelating therapy before and/or after transplantation is a promising strategy to improve the clinical outcomes of transplant patients with iron overload, but further research is needed to prove the direct relationship between iron overload and adverse outcomes.

Iron overload and allogeneic hematopoietic stem-cell transplantation

Iron-chelating therapy before and/or after transplantation is a promising strategy to improve the clinical outcomes of transplant patients with iron overload, but further research is needed to prove the direct relationship between iron overload and adverse outcomes.

Toxicity of iron overload and iron overload reduction in the setting of hematopoietic stem cell transplantation for hematologic malignancies.

The management of iron overload in allogeneic hematopoietic stem cell transplant (alloHSCT) recipients: Where do we stand?

Iron overload, primarily related to multiple red blood cell transfusions, is a relatively common complication in hematopoietic stem cell transplant (HSCT) recipients and efforts have been directed toward identifying alternative treatment for IO in alloHSCT recipients to maintain improved transplant outcomes.

Disturbance of pro-oxidative/antioxidative balance in allogeneic peripheral blood stem cell transplantation.

There is a significant disturbance of pro-oxidative/antioxidative balance in the plasma of patients undergoing allogeneic HSCT regardless of the intensity of the conditioning regimen, and their relationships with graft-versus-host disease, conditioning regimens, and transplant-related mortality are investigated.

Iron overload, hematopoietic cell transplantation, and graft-versus-host disease

Many patients who undergo hematopoietic cell transplantation (HCT) present with anemia and have received red blood cell transfusions before HCT. As a result, iron overload is frequent and appears to…

When is iron overload deleterious, and when and how should iron chelation therapy be administered in myelodysplastic syndromes?

Iron Overload and Hematopoetic Stem Cell Transplantation

Hematopoietic stem cell transplantation is an established treatment modality with a curative potential in a variety of hematological disorders and IO has a substantial role as a contributor to quality of life.

Iron Overload in Patients Undergoing Hematopoietic Stem Cell Transplantation

Accumulating evidence has established the negative impact of elevated pretransplantation serum ferritin, a surrogate marker of iron overload, on overall survival and nonrelapse mortality after HSCT, and particular attention should be paid to prevention and management in allogeneic HSCT candidates, especially in patients with thalassemia and myelodysplastic syndromes.

New insights into transfusion-related iron toxicity: Implications for the oncologist.

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References

SHOWING 1-10 OF 127 REFERENCES

Blood Radicals: Reactive Nitrogen Species, Reactive Oxygen Species, Transition Metal Ions, and the Vascular System

Considerable evidence supports the view that oxidative damage involving both ROS and RNS is an important contributor to the development of atherosclerosis.

High levels of peroxynitrite are generated in the lungs of irradiated mice given cyclophosphamide and allogeneic T cells. A potential mechanism of injury after marrow transplantation.

It is concluded that allogeneic T cells stimulate macrophage-derived reactive oxygen/nitrogen species, and that the addition of Cy favors peroxynitrite formation, which clarifies the dependence of Cy-induced lung injury and lethality on the presence of allogeneIC T cells.

Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage.

It is demonstrated that reduced ferrohemoglobin, while relatively innocuous to cultured endothelial cells, when oxidized to ferrihemoglobin (methemoglobin), greatly amplifies oxidant (H2O2)-mediated endothelial-cell injury.

Impaired plasma antioxidative defense and increased nontransferrin-bound iron during high-dose chemotherapy and radiochemotherapy preceding bone marrow transplantation.

Iron: mammalian defense systems, mechanisms of disease, and chelation therapy approaches.

Iron chelators for the treatment of iron overload disease: Relationship between structure, redox activity, and toxicity

Interestingly, toxicity does not necessarily correlate with Fe‐binding affinity or with chelation efficacy, suggesting that other factors may promote the cytopathic effects of chelators.

Deteriorating free radical-trapping capacity and antioxidant status in plasma during bone marrow transplantation.

Monitoring of the antioxidant status before and after BMT revealed a breakdown of plasma antioxidant defence and of radical-vulnerable lipids, which was associated with high circulating levels of iron.

Iron overload might increase transplant-related mortality in haematopoietic stem cell transplantation

VHL of ferritin and TS ⩾100% at conditioning are associated with an increase in toxic deaths after transplant.

Iron and chronic viral hepatitis: emerging evidence for an important interaction.

Whether iron removal will prove useful in the long-term management of chronic viral hepatitis is an issue in need of further well-designed, randomized, controlled trials.

Endothelial cell heme oxygenase and ferritin induction in rat lung by hemoglobin in vivo.

It is speculated that methemoglobin, which might be generated by activated leukocytes in ARDS associated with disseminated interavascular coagulation, can provide heme iron to lung microvascular endothelium to induce heme oxygenase and ferritin.
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