• Corpus ID: 14824018

Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF).

  title={Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF).},
  author={Manuel Merlos and Marta Giral and Dolors Balsa and Rosa Ferrando and Mireia Queralt and Anna Puigdemont and Juli{\'a}n Garc{\'i}a-Rafanell and Javier Forn},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={280 1},
  • M. MerlosM. Giral J. Forn
  • Published 1997
  • Biology, Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
Rupatadine (UR-12592, 8-chloro-6, 11-dihydro-11-[1-[(5-methyl3-pyridinyl) methyl]-4-piperidinylidene]-5H-benzo[5,6]-cyclohepta[1,2b]pyridine ) is a novel compound that inhibits both platelet-activating factor (PAF) and histamine (H1) effects through its interaction with specific receptors (Ki(app) values against [3H]WEB-2086 binding to rabbit platelet membranes and [3H]-pyrilamine binding to guinea pig cerebellum membranes were 0.55 and 0.10 microM, respectively). Rupatadine competitively… 

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