Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation.

@article{Fainaru2004Runx3RM,
  title={Runx3 regulates mouse TGF-beta-mediated dendritic cell function and its absence results in airway inflammation.},
  author={Ofer Fainaru and Eilon Woolf and Joseph Lotem and Merav Yarmus and Ori Brenner and Dalia Goldenberg and Varda Negreanu and Yael Bernstein and Ditsa Levanon and Steffen Jung and Yoram Groner},
  journal={The EMBO journal},
  year={2004},
  volume={23 4},
  pages={969-79}
}
Runx3 transcription factor regulates cell lineage decisions in thymopoiesis and neurogenesis. Here we report that Runx3 knockout (KO) mice develop spontaneous eosinophilic lung inflammation associated with airway remodeling and mucus hypersecretion. Runx3 is specifically expressed in mature dendritic cells (DC) and mediates their response to TGF-beta. In the absence of Runx3, DC become insensitive to TGF-beta-induced maturation inhibition, and TGF-beta-dependent Langerhans cell development is… CONTINUE READING
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