Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons

  title={Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons},
  author={Ken-ichi Inoue and Shigeru Ozaki and Takashi Shiga and Kosei Ito and Tomoyuki Masuda and Nobuo Okado and Tsutomu Iseda and Saburo Kawaguchi and Masaharu Ogawa and S C Bae and Namiko Yamashita and Shigeyoshi Itohara and Norio Kudo and Yoshiaki Ito},
  journal={Nature Neuroscience},
Dorsal root ganglion (DRG) neurons specifically project axons to central and peripheral targets according to their sensory modality. The Runt-related genes Runx1 and Runx3 are expressed in DRG neuronal subpopulations, suggesting that they may regulate the trajectories of specific axons. Here we report that Runx3-deficient (Runx3−/−) mice displayed severe motor discoordination and that few DRG neurons synthesized the proprioceptive neuronal marker parvalbumin. Proprioceptive afferent axons… CONTINUE READING


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