Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons

@article{Inoue2002Runx3CT,
  title={Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons},
  author={Ken-ichi Inoue and Shigeru Ozaki and Takashi Shiga and Kosei Ito and Tomoyuki Masuda and Nobuo Okado and Tsutomu Iseda and Saburo Kawaguchi and Masaharu Ogawa and S C Bae and Namiko Yamashita and Shigeyoshi Itohara and Norio Kudo and Yoshiaki Ito},
  journal={Nature Neuroscience},
  year={2002},
  volume={5},
  pages={946-954}
}
Dorsal root ganglion (DRG) neurons specifically project axons to central and peripheral targets according to their sensory modality. The Runt-related genes Runx1 and Runx3 are expressed in DRG neuronal subpopulations, suggesting that they may regulate the trajectories of specific axons. Here we report that Runx3-deficient (Runx3−/−) mice displayed severe motor discoordination and that few DRG neurons synthesized the proprioceptive neuronal marker parvalbumin. Proprioceptive afferent axons… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 42 references

and expression of a human RUNX 1 - CBF 2 T 1 transgene advances a model for studies of leukemogenesis

M. R. Celio
2002

Spatial and temporal expression pattern of Runx3 (Aml2) and Runx1 (Aml1) indicates non-redundant functions during mouse embryogenesis

D Levanon
Mech. Dev. 109, • 2001

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