Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation.

  title={Runx3/AML2/Cbfa3 regulates early and late chondrocyte differentiation.},
  author={Do Yu Soung and Yufeng Dong and Yongjun Wang and Michael J Zuscik and Edward M Schwarz and Regis J O'keefe and Hicham Drissi},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={22 8},
UNLABELLED We studied the expression and function of Runx3 during chondrogenesis and chondrocyte maturation. We found that Runx3 is essential for mediating the early stage of endochondral ossification through cooperation with other Runx family members. INTRODUCTION Runx proteins are spatially and temporally co-expressed during skeletal formation. A cooperative and/or redundant function between these factors was postulated, yet the mechanisms underlying these cooperative effects are unknown… CONTINUE READING


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