Runx2 is essential for larval hyobranchial cartilage formation in Xenopus laevis.

@article{Kerney2007Runx2IE,
  title={Runx2 is essential for larval hyobranchial cartilage formation in Xenopus laevis.},
  author={Ryan R Kerney and Joshua B. Gross and James Hanken},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2007},
  volume={236 6},
  pages={1650-62}
}
The vertebrate transcription factor protein Runx2 is regarded as a "master regulator" of bone formation due to the dramatic loss of the osseous skeleton in the mouse homozygous knockout. However, Runx2 mRNA also is expressed in the pre-hypertrophic cartilaginous skeleton of the mouse and chicken, where its developmental function is largely unknown. Several tiers of Runx2 regulation exist in the mouse, any of which may account for its seeming biological inactivity during early stages of… CONTINUE READING
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Normal table of Xenopus laevis (Daudin)

  • PD Nieuwkoop, J. Faber
  • New York: Garland Publishing. 252 p.
  • 1994
Highly Influential
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