Runx2 and dental development.

  title={Runx2 and dental development.},
  author={Simon Camilleri and F Crisp McDonald},
  journal={European journal of oral sciences},
  volume={114 5},
The Runx2 gene is a master transcription factor of bone and plays a role in all stages of bone formation. It is essential for the initial commitment of mesenchymal cells to the osteoblastic lineage and also controls the proliferation, differentiation, and maintenance of these cells. Control is complex, with involvement of a multitude of factors, thereby regulating the expression and activity of this gene both temporally and spatially. The use of multiple promoters and alternative splicing of… CONTINUE READING
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