Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth.

@article{Wang2005Runx2I,
  title={Runx2 (Cbfa1) inhibits Shh signaling in the lower but not upper molars of mouse embryos and prevents the budding of putative successional teeth.},
  author={Xiu-ping Wang and Thomas {\AA}berg and Martyn John James and Ditsa Levanon and Yoram Groner and Irma Thesleff},
  journal={Journal of dental research},
  year={2005},
  volume={84 2},
  pages={138-43}
}
Heterozygous mutations in the RUNX2 (CBFA1) gene cause cleidocranial dysplasia, characterized by multiple supernumerary teeth. This suggests that Runx2 inhibits successional tooth formation. However, in Runx2 knockout mice, molar development arrests at the late bud stage, and lower molars are more severely affected than upper ones. We have proposed that compensation by Runx3 may be involved. We compared the molar phenotypes of Runx2/Runx3 double-knockouts with those of Runx2 knockouts, but… CONTINUE READING