Runx2, a multifunctional transcription factor in skeletal development.

  title={Runx2, a multifunctional transcription factor in skeletal development.},
  author={Toshihisa Komori},
  journal={Journal of cellular biochemistry},
  volume={87 1},
The identification of Runx2 (runt-related protein 2) function has greatly advanced the understanding of skeletal development over the last 5 years. Runx2 is regulated transcriptionally and post-translationally through the activity of many identified factors, although, the physiological significance of each remains to be demonstrated. The interaction of Runx2 with other transcription factors and cofactors has been shown to be important in Runx2-dependent gene regulation. Runx2 plays important… CONTINUE READING
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