Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult.

  title={Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult.},
  author={Lena Motoda and Motomi Osato and Namiko Yamashita and Bindya Jacob and Lynnette Q Chen and Masatoshi Yanagida and Hiroshi Ida and H Wee and Alfred X. Sun and Ichiro Taniuchi and Dan K. Littman and Yoshiaki Ito},
  journal={Stem cells},
  volume={25 12},
The RUNX1/AML1 gene encodes a transcription factor essential for the generation of hematopoietic stem cells and is frequently targeted in human leukemia. In human RUNX1-related leukemias, the RAS pathway is often concurrently mutated, but the mechanism of the synergism remains elusive. Here, we found that inactivation of Runx1 in mouse bone marrow cells results in an increase in the stem/progenitor cell fraction due to suppression of apoptosis and elevated expression of the polycomb gene Bmi-1… CONTINUE READING


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