Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation.

@article{Osorio2008Runx1MD,
  title={Runx1 modulates developmental, but not injury-driven, hair follicle stem cell activation.},
  author={Karen M. Osorio and Song Eun Lee and David James McDermitt and Sanjeev K. Waghmare and Ying Zhang and Hyun Nyun Woo and Tudorita Tumbar},
  journal={Development},
  year={2008},
  volume={135 6},
  pages={1059-68}
}
Aml1/Runx1 controls developmental aspects of several tissues, is a master regulator of blood stem cells, and plays a role in leukemia. However, it is unclear whether it functions in tissue stem cells other than blood. Here, we have investigated the role of Runx1 in mouse hair follicle stem cells by conditional ablation in epithelial cells. Runx1 disruption affects hair follicle stem cell activation, but not their maintenance, proliferation or differentiation potential. Adult mutant mice exhibit… CONTINUE READING