Runx1 is required for hematopoietic defects and leukemogenesis in Cbfb-MYH11 knock-in mice

@article{Hyde2015Runx1IR,
  title={Runx1 is required for hematopoietic defects and leukemogenesis in Cbfb-MYH11 knock-in mice},
  author={R. Katherine Hyde and Ling Zhao and Lemlem Alemu and Pu Liu},
  journal={Leukemia},
  year={2015},
  volume={29},
  pages={1771-1778}
}
CBFβ-SMMHC (core-binding factor β-smooth muscle myosin heavy chain), the fusion protein generated by the chromosome 16 inversion fusion gene, CBFB-MYH11, is known to initiate leukemogenesis. However, the mechanism through which CBFβ-SMMHC contributes to leukemia development is not well understood. Previously, it was proposed that CBFβ-SMMHC acts by dominantly repressing the transcription factor RUNX1 (Runt-related protein 1), but we recently showed that CBFβ-SMMHC has activities that are… CONTINUE READING
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CBFB - MYH 11 / RUNX 1 together with a compendium of hematopoietic regulators , chromatin modi fi ers and basal transcription factors occupies self - renewal genes in inv ( 16 ) acute myeloid

  • A Mandoli, AA Singh, PW Jansen, AT Wierenga, H Riahi, G Franci
  • LEUKEMIA
  • 2013

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