Runx1 is involved in primitive erythropoiesis in the mouse.

Abstract

Targeted disruption of the Runx1/ AML1 gene in mice has demonstrated that it is required for the emergence of definitive hematopoietic cells but that it is not essential for the formation of primitive erythrocytes. These findings led to the conclusion that Runx1 is a stage-specific transcription factor acting only during definitive hematopoiesis. However… (More)
DOI: 10.1182/blood-2007-05-091637

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