Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancer

@inproceedings{Bowers2010Runx1BA,
  title={Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancer},
  author={Sarion R. Bowers and Fernando J. Calero-Nieto and Stephanie Valeaux and Narc{\'i}s Fernandez-Fuentes and Peter N. Cockerill},
  booktitle={Nucleic acids research},
  year={2010}
}
Runx1 is a developmentally regulated transcription factor that is essential for haemopoiesis. Runx1 can bind as a monomer to the core consensus sequence TGTGG, but binds more efficiently as a hetero-dimer together with the non-DNA binding protein CBFβ as a complex termed core binding factor (CBF). Here, we demonstrated that CBF can also assemble as a dimeric complex on two overlapping Runx1 sites within the palindromic sequence TGTGGCTGCCCACA in the human granulocyte macrophage colony… CONTINUE READING