Runx1 Regulates Myeloid Precursor Differentiation Into Osteoclasts Without Affecting Differentiation Into Antigen Presenting or Phagocytic Cells in Both Males and Females.

@article{Paglia2016Runx1RM,
  title={Runx1 Regulates Myeloid Precursor Differentiation Into Osteoclasts Without Affecting Differentiation Into Antigen Presenting or Phagocytic Cells in Both Males and Females.},
  author={David N. Paglia and Xiaochuan Yang and Judith F Kalinowski and Sandra L Jastrzebski and Hicham Drissi and Joseph A. Lorenzo},
  journal={Endocrinology},
  year={2016},
  volume={157 8},
  pages={
          3058-69
        }
}
Runt-related transcription factor 1 (Runx1), a master regulator of hematopoiesis, is expressed in preosteoclasts. Previously we evaluated the bone phenotype of CD11b-Cre Runx1(fl/fl) mice and demonstrated enhanced osteoclasts and decreased bone mass in males. However, an assessment of the effects of Runx1 deletion in female osteoclast precursors was impossible with this model. Moreover, the role of Runx1 in myeloid cell differentiation into other lineages is unknown. Therefore, we generated… CONTINUE READING