Runx1/AML1 in leukemia: disrupted association with diverse protein partners.

@article{Perry2002Runx1AML1IL,
  title={Runx1/AML1 in leukemia: disrupted association with diverse protein partners.},
  author={Chava Perry and Amiram Eldor and Hermona Soreq},
  journal={Leukemia research},
  year={2002},
  volume={26 3},
  pages={221-8}
}
Runx1/AML1, a chromosome 21q22 hematopoietic regulator, is frequently translocated in leukemia. Its protein product, a relatively weak transcriptional activator, becomes an effective transcriptional enhancer or repressor, when co-operating with transcriptional co-activators or co-repressors. Runx1/AML1 association with its partners is disrupted in leukemia. For example, Runx1/AML1 mutations and translocations (e.g. t(8;21), t(12;21) and t(3;21)) impair binding of Runx1/AML1-CBFbeta complexes to… CONTINUE READING